Just a few days after his debut, Cristian Romero also scored his first goal with the Argentina shirt in the qualifiers for the FIFA World Cup Qatar 2022. The match was a 2-2 draw against Colombia that took place in Barranquilla. Romero opened the scoring after three minutes with a masterful header. Another Atalanta player led the Colombian comeback, Luis Muriel, who came on at the half-hour mark of the first half and converted the penalty that temporarily made it 1-2 at the start of the second half. Duván Zapata played for the first forty-five minutes, while José Palomino did not play for Argentina.